​The FIZZ Cube is located in the NPD-strook. The NPD-strook, or Dutch Parcel Service strip, is part of Overvecht-Zuid. In 1965, a 'bodecentrum' or transport hub was built in this neighborhood in order to alleviate delivery trucks and heavy goods traffic from the city center. When it opened, this transport hub was the largest in Europe. In 1969-1970, an office for the Animal Health Service was opened to the west of the transport hub at Montalbaendreef 2.